17BT46 Clinical Biochemistry syllabus for BT



A d v e r t i s e m e n t

Module-1 DISORDERS OF CARBOHYDRATE METABOLISM 10 hours

DISORDERS OF CARBOHYDRATE METABOLISM:

Diabetes mellitus, glycohemoglobins, hypo-glycemias, galactosemia and ketone bodies. Various types of glucose tolerance tests. Glycogen storage diseases. Physiology of lipids/lipoproteins. Lipidosis. Clinical inter-relationships of lipids (sphingolipidosis and multiple sclerosis), lipoproteins and apolipoproteins. Diagnostic tests for HDL-cholesterol, LDL-cholesterol and triglyceride disorders.

Module-2 INBORN ERRORS OF METABOLISM 10 hours

INBORN ERRORS OF METABOLISM:

a) Disorders of amino acid metabolism - Phenylalanemia, homocystinuria, tyrosinemia, MSUD, phenylketonuria, alkaptonuria, albinism and animoacidurias. b) Disorders of nucleic acid metabolism- Disorders in purine/ pyrimidine metabolism.

Module-3 DISORDERS OF ACID-BASE BALANCE AND THEIR RESPIRATORY AND RENAL MECHANISMS 10 hours

DISORDERS OF ACID-BASE BALANCE AND THEIR RESPIRATORY AND RENAL MECHANISMS:

Evaluation of organ function tests,Assessment and clinical manifestations of renal, hepatic, pancreatic, gastric and intestinal functions. Clinical importance of bilirubin. Diagnostic enzymes: Principles of diagnostic enzymology. Clinical significance of aspartate aminotransferase, alanine aminotransferase, creatine kinase, aldolase and lactate dehydrogenase. Enzyme tests in determination of myocardial infarction. Enzymes of pancreatic origin and biliary tract

Module-4 HORMONAL DISTURBANCES 10 hours

HORMONAL DISTURBANCES

Protein hormones (anterior pituitary hormones, posterior pituitary hormones), steroid hormones, adrenocorticosteroids, and reproductive endocrinology. Disturbances in thyroid function. Disorders of mineral metabolism: Hypocalcaemia, hypocalcaemia, normocalcaemia, hypophosphatemia and hypophosphatemia.

Module-5 BIOCHEMICAL ASPECTS OF HEMATOLOGY 10 hours

BIOCHEMICAL ASPECTS OF HEMATOLOGY:

Disorders of erythrocyte metabolism, hemoglobinopathies, thalessemias thrombosis and anemias. Laboratory tests to measure coagulation and thrombolysis. Detoxification in the body: enzymes of detoxification, polymorphism in drug metabolizing enzymes. Mechanism of drug action and channels of its excretion, Disorders of vitamins and trace elements.

 

Course outcomes:

After studying this course, students will be able to:

  • Discuss the biochemistry and pathophysiology associated with various disorders of metabolism and inborn errors of metabolism.
  • Describe the structure and function of metabolic pathways for carbohydrates, amino acids and lipids.
  • Explain the medical problems associated with abnormal lipoprotein levels and therapeutic agents used to treat lipid disorders.
  • Assess the clinical manifestations of renal, hepatic, pancreatic, gastric andintestinal functions.

 

REFERENCE BOOKS

1. Review of Medical Physiology (Lange Basic Science) (Paperback) By William F. Ganong. Publisher: McGraw-Hill Medical

2. Harper's Biochemistry (Lange Medical Books) (Paperback) By Robert K. Murray, Daryl K. Granner, Peter A. Mayes and Victor W. Rodwell. Publisher: Appelton and Lange. 8. Clinical Biochemistry by Richard Luxton. Scion Publishing Ltd.

3. Clinical Biochemistry Paperbackby Nanda Maheshwari, 2008.

4. Appreciate the biochemical aspects of hematology.

 

TEXT BOOKS

1. Textbook of Medical Biochemistry by MN Chatterjea and Rana Shinde, JaypeeBrothers.

2. Lehninger- Principles of Biochemistry by David L. Nelson and Michael M. Cox, 5th Edition, WH Freeman and Company.

3. Medical Biochemistry (Paperback) By John W. Baynes and Marek Dominiczak. Publisher: Mosby.

4. Clinical Biochemistry: 3rd Ed By Allan Gaw, Michael Murphy, Robert Cowan, Denis O'Reilly, Michael Stewart and James Shepherd. Publisher: Churchill Livingstone.

Last Updated: Tuesday, January 24, 2023

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